jaundice (yellowing of the skin or eyes). Keep a notepad next to your medications and jot down the times you take a dose, what you take, and how much. Is It Safe To Take Acetaminophen With Ibuprofen? It acts as a precursor for glutathione, promoting normal conjugation of any remaining paracetamol, and also supplies thiols that function as antioxidants. Answer (1 of 8): What will happen if I take Prozac 20 mg daily? You may not be able to take Tylenol. (n.d.). If your pain isn't being controlled by ibuprofen and the maximum dosage of tylenol it would be time to consider a stronger pain reliever. If the damage is severe, a liver transplant may be necessary in order to save someones life. Indeed, NAC can prevent liver failure if given early enough. Heres How To Stop Drinking, 6 Sore Throat Remedies That Actually Work. Children younger than 12 years old should not take more than 5 doses in 24 hours, using only the number of milligrams per dose that is recommended for the child's weight and age. Yes. HealthTap uses cookies to enhance your site experience and for analytics and advertising purposes. Can you take aspirin and ibuprofen together to treat or prevent different conditions? It is used for the treatment of pain and to lower fever. Altman T, et al., eds. Your doctor may adjust the dose as needed. Acetaminophen does not cause the stomach upset these other painkillers can cause, but its relationship to liver toxicity has worried the agency for years. Ask your healthcare provider or a pharmacist if you have questions about dosing instructions or medicines with acetaminophen. This content does not have an Arabic version. Most of the time, acetaminophen overdose can be treated. For infants ages 6 months to 1 year, the safe dose of the infant formulation depends on their weight. Tylenol is a pain reliever and a fever reducer. One cited study even showed that overuse of acetaminophen can. Brendan Smialowski/Getty Images You can take these steps to avoid acetaminophen overdose: If you or a family member is depressed and suicidal, remove all medications and dangerous substances from the house and seek medical attention immediately. Her dose was equal to ingesting 10 grams of acetaminophen. What's the best sore throat medicine to use? Current guidelines note the maximum daily dose is 3 grams (equal to 3,000 milligrams) of Tylenol a day. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. In the United States, you can reach the poison center by calling 1-800-222-1222. SOURCE: Acetaminophen (Tylenol) Poisoning from eMedicineHealth. Ask your healthcare provider or pharmacist if you have questions about dosing instructions or medicines that contain acetaminophen. What medications cause liver enzymes to be elevated? Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. If someone is suspected of having taken an overdose but has no symptoms, the doctor will begin the following treatment: After being discharged from the hospital or doctor's office, you may be asked to return for an examination or blood tests to check the condition of your liver and your general health. Use these dosage charts for infants and children under 12 years old: Take Tylenol exactly as directed on the label, or as prescribed by your doctor. This medicine should also come with a Medication Guide. Luckily, a secondary substance called glutathione helps minimize the toxic effects. Do not take acetaminophen if you consume alcoholic beverages. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Tylenol only for the indication prescribed. With prompt medical treatment, youre likely to recover from an ibuprofen overdose. (2016, September 6). Accidental Prophylaxis With N-acetylcysteine in Intentional Acetaminophen Overdose. If you understand what happens when you take a drug through the following graphs, you will understand the science behind adherence. Kuffner E. (n.d.). Taking more than the recommended dosage of ibuprofen or drinking a lot of alcohol significantly raises your risk of serious problems. Acetaminophen vs Ibuprofen: Which is better? Healthline Media does not provide medical advice, diagnosis, or treatment. Also, talk to your healthcare provider before taking acetaminophen if you: You may be at greater risk of liver damage. That makes it much easier to accidentally overdose on pain relievers. A safe dose for children is much less than that. A child's dose is based on age and weight. My parents were called and I was driven to the nearest hospital and checked into. You can call this number 24 hours a day. In rare cases, an overdose can be fatal. Advertising on our site helps support our mission. starting to feel sick, stomach pain & dizzy. Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. It's just Tylenol, Ma." All rights reserved. Older adults and those with liver damage may need to keep their daily maximum even lower than these recommendations. Read and carefully follow any Instructions for Use provided with your medicine. Read about side effects, warnings, and other factors to help you decide which fever reducer is best for you or your. According to research, do not take any of the following medications with ibuprofen without first talking with your doctor: Mixing ibuprofen with alcohol can also increase your risk of having serious side effects, like stomach or intestinal bleeding. Treatment may include medications that help remove the acetaminophen from the body or lessen its harmful effects. When you take a drug, it is absorbed into the blood and distributed round the body. Receive a bonus guide on ways to manage your childs health just for subscribing. Soon after this, the drug level falls steadily as its is . There are many options for non-narcotic pain medications. Is it harmful to takeacetaminophen (Tylenol) after a few drinks? of the med and pharmacists can be conta. Stay on the line for further instructions. If a toxic dose is taken and emergency treatment is delayed, liver failure may follow. Do not keep outdated medicine or medicine no longer needed. Oxycodone and acetaminophen combination can cause serious unwanted effects or fatal overdose if taken by children, pets, or adults who are not used to strong narcotic pain medicines. Or seek emergency care if you're concerned about a possible acetaminophen overdose or notice early signs or symptoms of an overdose. There's not a lot of current information on how serious the situation is. The recommended dosage for adults is one or two 200-milligram (mg) tablets every 4 to 6 hours. Acetaminophen is in Actifed, Alka-Seltzer Plus, Benadryl, Co-Gesic, Contac, Excedrin, Fioricet, Lortab, Midrin, Norco, Percocet, Robitussin, Sedapap, Sinutab, Sudafed, TheraFlu, Unisom PM Pain, Vick's Nyquil and DayQuil, Vicodin, and Zydone. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. FDA recommends health care professionals discontinue prescribing and dispensing prescription combination drug products with more than 325 mg of acetaminophen to protect consumers, U.S. Food and Drug Administration. Acetaminophen is the active ingredient in Tylenol. Ibuprofen toxicity. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. If you experience symptoms of an ulcer after taking ibuprofen, stop taking ibuprofen and call your doctor. Drug record: Acetaminophen, knowyourdose.org/acetaminophen-for-infants-and-children/, fda.gov/downloads/AdvisoryCommittees//UCM164897.pdf, raps.org/Regulatory-Focus/News/2015/11/16/23608/FDA-Amends-Liver-Warning-Labeling-Guidance-for-Some-OTC-Drugs-Containing-Acetaminophen/, mayoclinic.com/health/acetaminophen/HO00002, merckmanuals.com/home/injuries-and-poisoning/poisoning/acetaminophen-poisoning, poison.org/articles/2009-dec/acetaminophen-take-it-safely, Zara Risoldi Cochrane, Pharm.D., M.S., FASCP, Ibuprofen (Advil) Side Effects: What You Need to Know. About 0.4% of those who overdose die from liver toxicity and failure. Connect with a U.S. board-certified doctor by text or video anytime, anywhere. EDIT^1: 4000 mg tylenol max for no longer than a week. Carefully check the labels of all other medicines you are using, because they may also contain acetaminophen. Since Tylenol is taken as needed, you may not be on a dosing schedule. Over-the-Counter Medicine for Toothache Pain. Less serious Tylenol side effects may be more likely, and you may have none at all. Tylenol (Acetaminophen Capsules and Tablets). The FDA currently recommends that anyone taking medications that contain acetaminophen should not drink alcoholic beverages. Liver failure may mean that a liver transplant is needed to prevent death. Your doctor will determine whether Tylenol is safe for you to use during pregnancy. But if you have liver disease or a drinking problem, even that may be too much. You can call 24 hours a day, every day. Tylenol is used to reduce fever and relieve minor pain caused by conditions such as colds or flu, headache, muscle aches, arthritis, menstrual cramps and fevers. If you cant access a phone or computer, go to the nearest emergency room immediately. Here is the link to the FDA safe disposal of medicines website:www.fda.gov/drugs/resourcesforyou/consumers/buyingusingmedicinesafely/ensuringsafeuseofmedicine/safedisposalofmedicines/ucm186187.htm . Securely replace child-resistant caps after using medication. If you or someone you know has taken more than the recommended dose, call your local poison center or your local emergency services. Signs of problems include nausea, vomiting, jaundice and tenderness in the upper right abdomen. ChildrenUse and dose must be determined by your doctor. Check out these five surprising options. Answer (1 of 7): I actually did this about 6 months ago. Is it safe to take acetaminophen every day? Retrieved from, Brennan, Z. However, if you take too much acetaminophen, or if the liver does not have an abundant reserve of glutathione, the toxic metabolite can accumulate and cause significant damage to your liver. However, the dose is usually not more than 60 mL (12 teaspoons) per day. For instance, if you are sleep-deprived or hungry, taking a nap or eating a nutritious snack may soothe your headache. Motrin dosing charts for children and infants. However, if you regularly drink more than the recommended number of alcoholic drinks per day, youd be best off to only use acetaminophen in rare instances and avoid daily doses greater than 4,000 mg. , Cleveland Clinic is a non-profit academic medical center. Acetaminophen is only for mild to moderate pain. To stay safe, make sure to do the following when you use acetaminophen: Last medically reviewed on October 7, 2016. Do not take extra medicine to make up the missed dose. For this reason, you should always take it exactly as directed on the label or as recommended by your doctor. Accessed Feb. 24, 2022. Acetaminophen overdose is one of the most common poisonings. Learn about ibuprofen side effects here, including common ones, such as stomach. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. We comply with the HONcode standard for trustworthy health information. In some cases, it can even be fatal. Our website services, content, and products are for informational purposes only. You can also check the DEA web site for locations. Cleveland Clinic 1995-2023. The same report notes that acetaminophen overdose accounts for82,000 emergency room visits and 26,000 hospitalizations each year. Soliman M, Soliman Y, Gurell M. Long Live the Liver! Someone who has overdosed may be admitted to the hospital or treated in the emergency department. Click here for an email preview. When your doctor writes you a prescription, it never hurts to ask him if he wants you to avoid OR do something in particular. Regular spoons vary in size and wont give an accurate dose. May cause gastrointestinal side effects at high dosages. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Mayo Clinic on Incontinence - Mayo Clinic Press, NEW The Essential Diabetes Book - Mayo Clinic Press, NEW Ending the Opioid Crisis - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press. Always read and follow the label. Portions of this document last updated: March 01, 2023. Your recommended dose of ibuprofen depends on your age. What You Need to Know About Tylenol Arthritis, Types of Tylenol: How to Choose, Dosage, Safety. Accidental Prophylaxis With N-acetylcysteine in Intentional Acetaminophen Overdose, Emergency department visits for overdoses of acetaminophen-containing products, People who take several acetaminophen medications at the same time. All rights reserved. Some people wont have any visible symptoms at all. Intentional or inadvertent acetaminophen overdosehow lethal it really is? Your doctor may instruct you to avoid alcohol and certain medications. We avoid using tertiary references. This combination medicine contains acetaminophen (Tylenol). You should not take Tylenol if you are allergic to acetaminophen, or if you have severe liver disease. The short answer: nobody knows. Extra Strength Tylenol is one of several common painkillers containing acetaminophen, an ingredient that is toxic in high doses. Do not use this medicine without the advice of your doctor if you are pregnant. The potential for liver damage exists, even at recommended dosages. ", FDA Recommends New Limits On Acetaminophen, Army Hospitals Struggle To Stop Drug Overdoses, Medication Error Death Rate Up 500 Percent, The Mayo Clinic On Acetaminophen And Children. How much Tylenol can I take for 85 pounds? Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. Consider putting the maximum amount you can take in a day in a separate pill bottle to avoid taking more than you should. Seek emergency medical care at a hospital's emergency department in the following situations: If the person suspected to have taken an overdose of acetaminophen is unconscious, semiconscious, or not breathing, call 911 immediately. Know if your medications contain acetaminophen. Dosage based on their weight is more accurate than dosage based on their age. How much acetaminophen does it take to kill you? If you are taking the medication regularly, take the missed dose as soon as you remember. Powder Packs. Ask your doctor before administering this medication. Last updated on Apr 28, 2022. Most Common Non-Narcotic Pain Medications, pain in the abdomen or belly, especially in the upper right side, using multiple medicines that contain acetaminophen at the same time. Can You Take Tylenol With an Aspirin or Aleve? And that's a big concern to the FDA and its advisory committee. hide caption. The pharmacist should do a consult with any prescription. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. Be extra cautious when taking 500 or 650 milligram pills. Click here for an email preview. (2014, January 1). Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Can you recover from an acetaminophen overdose? Check with your doctor first before changing dosage forms (eg, capsules, extended-release tablets, tablets). Learn how ricin poisoning occurs, the signs and symptoms of poisoning, and what to do if you're exposed. Children may also mistake acetaminophen for candy or juice and accidentally ingest it. Over-the-counter (otc) ibuprofen: Cardiovascular safety & consumer use. Learn how to use them together safely and the dangers of misusing either in combination. Accessed Feb. 24, 2022. You'll soon start receiving the latest Mayo Clinic health information you requested in your inbox. 2023 Dotdash Media, Inc. All rights reserved. Acetaminophen with codeine is a prescription pain medication. Avoid also using other medicines that contain acetaminophen, or you could have a fatal overdose. Together, acetaminophen and alcohol increase the chance of overdose and liver damage. TYLENOL Extra Strength Dissolve Packs. The outcome for someone who has an acetaminophen overdose depends largely on three factors: the amount of acetaminophen ingested, the timing of emergency treatment, and the initial general health of the person. Sign up for free, and stay up to date on research advancements, health tips and current health topics, like COVID-19, plus expertise on managing health. A doctor may insert a tube through the mouth to look for internal bleeding. Taking acetaminophen may cause false results with certain blood glucose monitors. This is not a complete list of side effects and others may occur. This is a rebound headache that forms as a result of taking headache medication too much. Read and follow these instructions carefully. You are reporting in your For a healthy individual, it is recommended to not use more than 3 grams in a 24 hour period. Are you thinking about overdosing? Ask your childs healthcare provider how much acetaminophen you should use, especially if your child is younger than 2 years old. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. And it narrowly called for banning prescription drugs like Vicodin and Percocet, which contain both acetaminophen and a narcotic. (2015, November 16). To avoid the side effects and possible toxicity of medications, you might turn to natural painkillers instead. Your body converts a very small byproduct of metabolized acetaminophen into a toxic substance that can be harmful to your liver. This can cause dangerous side effects such as damage to your stomach or intestines. However, acetaminophen is a common ingredient in many medications, and its possible to take too much without realizing it. Single doses over 1,500 milligrams and total daily doses over 4,000 milligrams have been shown to cause harm to individuals. Store at room temperature away from heat and moisture. Read it again each time you refill your prescription in case there is new information. Know the correct dose of acetaminophen and the amount of acetaminophen in the preparation you are using. According to the FDA, liver damage can occur if you take more than 4000 mg of acetaminophen within 24 hours. To learn more, please visit our, I would not, standard dose is usually 625mg oral every 6 hours. Also seek emergency care if you notice any symptoms of an overdose, such as loss of appetite, nausea and vomiting, or pain in the upper right side of the abdomen. McNeil Consumer Healthcare (the maker of Tylenol) lowered their recommended maximum daily dose to 3,000 mg. If people up their opioids to get more pain relief, they're taking more acetaminophen. Ask your doctor or pharmacist if you need help. If we combine this information with your protected This daily max is expected to be lowered soon. Learn about these two drugs and how to take each safely. You may take this medicine with or without food. Adults over 60 years old should take as little ibuprofen as possible to manage their symptoms. Higher dosage can harm y Dr. Elizabeth Finley-Belgrad and another doctor agree. Certain medications can increase your risk of having an overdose of ibuprofen. Copyright 2023 IBM Watson Health. However, if taken in excess amounts (overdose, whether on purpose or by accident), acetaminophen can cause life-threatening illness. Tylenol comes in many different forms such as tablets, caplets, capsules, liquid, chewable tablets, and dissolving powders or granules. Copyright 1996-2023 Cerner Multum, Inc. Acetaminophen-induced acute liver failure is more common and more severe in women. It may increase your risk of liver damage while taking Tylenol. Extra Strength Tylenol is one of several common painkillers containing acetaminophen, an ingredient that is toxic in high doses. In fact, both acetaminophen and alcohol utilize glutathione in the liver to temper their toxic effects. the toxic dose is variable in individuals.A single dose of 10 grms has a pretty Several factors. Write down this plan and follow it. Naproxen vs. Ibuprofen: Which Should You Take for Pain? Children younger than 12 years old: Do not take more than 5 doses of acetaminophen in 24 hours. But giving your child more than the recommended dose can lead to acetaminophen toxicity, which can cause liver damage and even death if untreated. Poison Control recommends that you tell your healthcare provider about all prescription and OTC medicines that youre taking to make sure that you arent taking too much acetaminophen. Acetaminophen poisoning. Avoid drinking alcohol. All Rights Reserved. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Check the label to see if a medicine contains acetaminophen or APAP. For oral dosage form (extended-release tablets): Adults2 tablets every 12 hours as needed. Patterns of acetaminophen use exceeding 4 grams daily in a hospitalized population at a tertiary care center, Long Live the Liver! Why a Dry January Is Good for Your Health, Done With Alcohol? Sign up for our Health Tip of the Day newsletter, and receive daily tips that will help you live your healthiest life. Measles vaccine: Can I get the measles if I've already been vaccinated? Tylenol made for infants comes with its own medicine dropper or oral syringe. 2005-2023 Healthline Media a Red Ventures Company. Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, Book: Mayo Clinic Guide to Raising a Healthy Child, Book: Mayo Clinic Family Health Book, 5th Edition, Newsletter: Mayo Clinic Health Letter Digital Edition. Each capsule contained 500 milligrams (half a gram) of acetaminophen. Ask your doctor if you have any questions. Always read product labels carefully and take the smallest amount of ibuprofen possible that will help relieve your symptoms. Acetaminophen (Tylenol) Poisoning Symptoms. If taken in recommended doses, there is no risk of poisoning from acetaminophen. Read our. In some cases, it can even be fatal. Continue reading, Paracetamol, Ofirmev, Arthritis Pain Relief, Feverall, +24 more. For example, a parent may give their child a dose of acetaminophen without realizing that the babysitter recently did the same. This content does not have an English version. The excess substance attacks your liver . Review/update the information highlighted below and resubmit the form. Follow your doctor's orders or the directions on the label. Policy. Tylenol Dosage for Children and Infants. Here are some do's and don'ts for avoiding an accidental overdose. include protected health information. According to an eight-year study conducted by the FDA during the 1990s, acetaminophen overdose caused 56,000 emergency room visits per year, and 458 deaths per year. Stick to recommended doses. You may opt-out of email communications at any time by clicking on Josephine Manuele, National Council on Patient InformationEducation (NCPIE), Acetaminophen Awareness Coalition. 2005 - 2023 WebMD LLC. Ibuprofen is an over-the-counter nonsteroidal anti-inflammatory drug (OTC NSAID) used to relieve inflammation, fever, and mild pain. Tylenol is a very effective pain-killing (analgesic) and fever-reducing (anti-pyretic) agent. The amount of medicine that you take depends on the strength of the medicine. Last updated on Jan 6, 2022. It is very important that you understand the rules of the Opioid Analgesic REMS program to prevent addiction, abuse, and misuse of oxycodone and acetaminophen combination. 2012;9:55. It's effective and available without a prescription. American Journal of Preventive Medicine. These forms are very different from each other. 2016;4(2). Acetaminophen is one of the most common medications found in households. Is It Safe to Take Aspirin and Ibuprofen Together? Enterovirus D68 and parechovirus: How can I protect my child? Our expert weighs in. The following chart shows how much ibuprofen a child can consume depending on their weight. The following information includes only the average doses of this medicine. Do not double doses. Make sure to keep all medications where children cant reach them. Acetaminophen is primarily metabolized by the liver. And the results could be serious liver problems. Take 2 powders every 8 hours while symptoms last Do not exceed 6 powders in 24 hours, unless directed by a doctor. Is It Safe to Mix Naproxen and Acetaminophen? The recommended maximum daily dose is 4,000 milligrams (mg) per day for adults. He currently serves at the Glasser Brain Tumor Center in Summit, New Jersey. That said, don't throw your bottle of pain relievers in the trash. Take only one medicine at a time that contains acetaminophen. Older adults have a higher risk of kidney and gastrointestinal side effects. 2005-2023 Healthline Media a Red Ventures Company. Read more: Acetaminophen and liver damage. Tell your healthcare provider about all prescription and OTC drugs that youre taking to make sure you arent taking too much acetaminophen. However, regular, heavy alcohol use (more than one drink daily for women or more than two drinks daily for men) combined with repeated daily doses of acetaminophen predisposes the liver to acetaminophen-associated toxicity. But it's likely the FDA will act in some manner. Overall it is important that anyone suspected to have taken an overdose of acetaminophen get treatment early, before symptoms occur. But before you pop more pills than directed, be aware that large doses of acetaminophen can lead to liver and kidney damage. Don't take more if the maximum dosage of medication doesn't give you relief. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Acetaminophen has a much narrower window of safety compared with ibuprofen and naproxen, and taking too much acetaminophen can cause a build-up of a toxic byproduct of acetaminophen, called NAPQI, that can damage the liver, sometimes leading to a liver transplant or death. what do i do? Before you know it, you have exceeded the recommended maximum dosage of acetaminophen which your liver cannot metabolize properly. These may include nausea, vomiting, lethargy and right upper abdominal pain. For adults, there's no clear number. Use only the number of milligrams per dose that is recommended for the child's weight and age. Ask a doctor before using this medicine if you are breastfeeding. (2019). Acetaminophen: Take it safely, U.S. Food and Drug Administration. The recommended maximum daily dose is 4,000 milligrams (mg) per day for adults.. An overdose of acetaminophen can damage your liver or cause death. According to the U.S. Food and Drug Administration (FDA), taking too much acetaminophen can damage your liver. All rights reserved. 20,000 Mg of anything is 20 grams. The FDA is considering the panel's recommendations and has not yet decided whether to reduce the daily dose. The agency issued new regulations for over-the-counter drugs in 2003 that contain acetaminophen, saying that acetaminophen content must be clearly listed. Outside of the United States, it may be called paracetamol. Acetaminophen and children: Why dose matters, OMalley, G. F., & OMalley, R. (n.d.). Other factors add to the risk of liver damage when taking acetaminophen. Taking both drugs in the same day may lead to unintentionally taking more than the maximum daily dose. Other differences Continue reading, Acetaminophen is only effective at relieving pain and fever, while ibuprofen relieves inflammation in addition to pain and fever. Take only one medication at a time that contains acetaminophen. When taken for pain in adults, Tylenol is dosed between 500 milligrams and 1,000 milligrams every four to six hours. information and will only use or disclose that information as set forth in our notice of Among the signs of acetaminophen toxicity are nausea, vomiting, breathing . Acetaminophen safety: Be cautious but not afraid. Other blood tests may be done to check the liver. But the side effects of the overdose caused kidney and liver damage resulting in organ failure. Let's look at the effects of this flowering, Although stingrays generally arent dangerous, they will sting when disturbed or stepped on accidentally. Some common reasons that people may accidentally take more than the recommended daily dose of acetaminophen include: People can also take several drugs that contain acetaminophen without even knowing it. But different people react differently: Some people can take more with no apparent damage, some can't; there's no way to predict. If your dose is different, do not change it unless your doctor tells you to do so. If possible, have the following information ready: You can also receive guidance by using the poison centers webPOISONCONTROL online tool. Find out how. The first signs of an acetaminophen overdose include loss of appetite, nausea, vomiting, stomach pain, sweating, and confusion or weakness. Go to the hospital's emergency department if the poison control center tells you to go. Its found in over-the-counter (OTC) and prescription medications. Acetaminophen in overdose can seriously damage the liver. Over many years, it has been used countless times by many people, and it has proven to be a safe and effective medication. Notice to industry: Final guidance for over-the-counter products that contain acetaminophen. Ershad M, et al. WebMD does not provide medical advice, diagnosis or treatment. People often think that this medicine is very safe.